Friday, April 14, 2017

Intracytoplasmic Sperm Injection (ICSI): How It Can Help You Get Pregnant?



There are many reasons leading to #infertilitybut one of the main causes is the inability of the sperm to travel all the way up to the uterus to fertilize an egg. This is caused by defective sperms and could be due to poor sperm quality, poor motility, etc. There are multiple reasons for this, and even #smoking, #obesity, #diabetes, #hypertension, etc. could be reasons.

Many technical advancements in #fertility treatments are available, and they try to keep the natural process of fertilization intact, at the same time improving the chances of success.

Intracytoplasmic sperm injection (#ICSI, often used as a standalone term iksee) improves the rate of fertilization, in that the sperm is directly injected into the egg. The environment of this artificial fertilization is completely controlled, and the fertilized egg is then placed into the womb for further growth. It is one of the recent methods of improving fertility, a part of ART (assisted reproductive technology).

Indications:
  1. Poor sperm perms motility.
  2. Semen where sperm concentration is low.
  3. Male infertility with unidentifiable cause.
  4. Poor sperm quality, with sluggish sperms.
  5. Ejaculation issues, such as retrograde ejaculation (semen is ejected into the bladder).
  6. Useful in couples who have failed IVF.
The following outlines some of the steps for both men and women before and during the procedure.

Before the procedure - men:
  1. First step is the sperm collection; a screening is first done.
  2. Sperms collection happens through either masturbation or directly from the testicles via a small incision.
  3. Sperms could be collected fresh or collected and frozen for later use.
Before the procedure – women:
  1. In the normal menstrual cycle, only a single egg is released. However, prior to ICSI, the woman is given #ovulation drugs, which are high-dose hormone injections prior to ovulation. This ensures multiple eggs are released, which are then retrieved for #fertilization in the external environment.
  2. Blood and urine are monitored regularly to identify the ovulation time, and eggs are collected within 24 to 36 hours of release.
During the procedure - How ICSI happens:
  1. A healthy egg is chosen and placed in a glass tube, and a sperm is introduced to ensure fertilization.
  2. This could be repeated in multiple tubes, and the most healthy one could be chosen to be implanted into the uterus.
  3. Some of the fertilized ones could be frozen for later use, in case the implanted embryo fails to grow as expected.
  4. The success rate for this procedure is quite high as the fertilization rate is almost 80 - 85 % 

Saturday, February 25, 2017

Donor Egg IVF - How Does It Work?


Donor egg IVF is used by more than 70 percent of infertile women above 45 years to conceive. More than 8,000 babies are born in the US to women of all age groups by this method of Assistive Reproductive Technologies (ART). This kind of fertility treatment will become even more popular, in the days to come, because of advances in the egg-freezing technology.
What are donor eggs?
Donor eggs are eggs given by a healthy, fertile woman to an infertile woman for in-vitro fertilisation or IVF.

How does the Donor Egg IVF program work?
Before you start this course of treatment, you must consult your doctor regarding its feasibility and effect on your health. Typically, the process has the following steps;

    1. After a donor has been identified, the infertile woman (referred to as ‘you’) and the donor are given medication so that the menstrual cycles of both are synchronised. You are also given medication so that your endometrium lining is ready for womb transfer.
    2. After their donation, the eggs are fertilised using the In Vitro Fertilization technique.
    3. Since the donor is under 35, not more than three embryos are transferred from her to your womb.
    4. Embryos are formed after fertilising donor egg with partner sperm.
In some cases, the embryos may be transferred after they have been fertilised. This line of treatment is undertaken to reduce the stress of this treatment on you.
In cases of men, the following procedures are followed;
    1. Unless the sperm belongs to another man, your partner will be required to give a sample of his sperm to check sperm quality.
    2. The partner must give another sample on the day the eggs are collected.
    3. In the next stage, the eggs and sperm are mixed together and in vitro fertilised.
Chances of success in Donor Egg IVF program
The chances of you conceiving through this program are 60-70%. This strike rate is significantly higher than a conventional IVF line of treatment.
How to start with Donor Egg IVF program?
    1. Finding an egg donor is not that difficult these days. You can find a donor through a fertility clinic, an egg bank, an egg donation agency, a family member or a close family friend. Donors coming from a frozen egg bank are usually screened for health and other reasons. Most donors are in the age group of 21-35 years.
    2. Make it legal i.e while getting donors is easy, the tricky part is to comply with the various legal issues. Consult your spouse, doctor and your attorney before taking this step.
    3. Get counselling i.e. you need expert counselling before you conceive because, let us face it, your baby is not your biological offspring. You and your spouse need to be adequately psychologically prepared for this important development in the family.

Wednesday, October 26, 2016

Artificial sweeteners may reduce fertility

BIONEWS - Artificial sweeteners may reduce fertility: Artificial sweeteners found in soft drinks may reduce female fertility, a study suggests...

WHO considers new definition of infertility that includes being single

BIONEWS - WHO considers new definition of infertility that includes being single: The World Health Organisation is considering making changes to the definition of infertility to recognise that every individual has the 'right to reproduce'...

Age does not increase risk of IVF or ICSI birth defects

BIONEWS - Age does not increase risk of IVF or ICSI birth defects: Bearing a child at a higher age does not increase risk of birth defects when the woman has received IVF or ICSI treatment to become pregnant, a recent study suggests...

Tuesday, August 9, 2016

BIONEWS - Blurred boundaries – the language of DNA

BIONEWS - Blurred boundaries – the language of DNA: The general public have appropriated the term DNA to mean much more than just the molecule itself. This may not be a problem most of the time but, in the case of donor eggs and sperm in particular, it's important that people are clear on what genetics and epigenetics really tell us...


With rising instance of Third party assisted pregnancies, this research gains importance and supports informed decisions for the affected parents to be.

BIONEWS - Australia's oldest IVF mother has baby at 62

BIONEWS - Australia's oldest IVF mother has baby at 62: A 62-year-old Tasmanian woman has become Australia's oldest mother to conceive using IVF...

What are the motivating factors?...